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KMID : 0378019910340050039
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New Medical Journal
1991 Volume.34 No. 5 p.39 ~ p.42
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Corneal and Lens Changes in a Patient on Longterm Chlorpromazine Therapy : A report of a case
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Abstract
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Chlorpromazine has been widely used in psychiatry, especially in the long term intensive treatment of chronic schizophrenic patients. It has become evident that there are late, cumulative, and possibly permanent changes arising after long term administration of large doses of chlorpromazine.
The author recently experienced a case which showed corneal and lens changes in a patient who has been received a large doses of chlorpromazine. These changes consisted of brown and white deposits, most marked in the axial part of the lens and cornea. They were situated in the anterior capsule and adjoining subcapsular part of the lens, and in the endothelium of the cornea. And no pigmentary changes of the retina was found.
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